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    方志杰, 郑楚杰, 强化龙. 甲泼尼龙琥珀酸钠不同给药方式治疗突发性耳聋临床疗效分析[J]. 蚌埠医科大学学报, 2022, 47(11): 1526-1529. DOI: 10.13898/j.cnki.issn.1000-2200.2022.11.011
    引用本文: 方志杰, 郑楚杰, 强化龙. 甲泼尼龙琥珀酸钠不同给药方式治疗突发性耳聋临床疗效分析[J]. 蚌埠医科大学学报, 2022, 47(11): 1526-1529. DOI: 10.13898/j.cnki.issn.1000-2200.2022.11.011
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    FANG Zhi-jie, ZHENG Chu-jie, QIANG Hua-long. Clinical efficacy of methylprednisolone sodium succinate with different administration modes in the treatment of sudden sensorin eural hearing loss[J]. Journal of Bengbu Medical University, 2022, 47(11): 1526-1529. DOI: 10.13898/j.cnki.issn.1000-2200.2022.11.011
    Citation: FANG Zhi-jie, ZHENG Chu-jie, QIANG Hua-long. Clinical efficacy of methylprednisolone sodium succinate with different administration modes in the treatment of sudden sensorin eural hearing loss[J]. Journal of Bengbu Medical University, 2022, 47(11): 1526-1529. DOI: 10.13898/j.cnki.issn.1000-2200.2022.11.011
    shu

    甲泼尼龙琥珀酸钠不同给药方式治疗突发性耳聋临床疗效分析

    Clinical efficacy of methylprednisolone sodium succinate with different administration modes in the treatment of sudden sensorin eural hearing loss

      摘要
    • 摘要:
      目的探讨甲泼尼龙琥珀酸钠不同给药方式对突发性耳聋的治疗效果。
      方法选取突发性耳聋病人322例，根据治疗方法不同分为静脉用甲泼尼龙琥珀酸钠组（A组）208例，鼓室内注射甲泼尼龙琥珀酸钠组（B组）114例，静脉用无效后鼓室内注射甲泼尼龙琥珀酸钠组（C组）67例。比较3组听阈、治疗效果和不良反应发生率，并分析基础疾病对疗效的影响。
      结果治疗前3组听阈差异无统计学意义（P>0.05）；治疗后听阈均明显低于治疗前（P < 0.01），且A组、B组听阈均低于C组（P < 0.05）。A组、B组总有效率均高于C组（P < 0.05），但A组与B组间总有效率差异无统计学意义（P>0.05）。B组总不良反应发生率明显低于其余2组（P < 0.01）。不伴有基础疾病组的总有效率明显高于伴有基础疾病组（P < 0.01）。
      结论鼓室内注射治疗优于静脉治疗，听力损失类型和程度及基础性疾病等均对预后有较大影响。制定治疗方法时，要详细评估病人的病情，采取合理的治疗方法。

       

      Abstract:
      ObjectiveTo investigate the therapeutic effect of methylprednisolone sodium succinate on sudden sensorin eural hearing loss.
      MethodsA total of 322 patients with sudden sensorin eural hearing loss were divided into intravenous methylprednisolone sodium succinate group(group A, n=208), intratympanic injection of methylprednisolone sodium succinate group(group B, n=114) and intratympanic injection of methylprednisolone sodium succinate group(group C, n=67).The hearing threshold, therapeutic effect and adverse reaction rate among the three groups were compared, and the influence of basic disease on the therapeutic effect was analyzed.
      ResultsThere was no significant difference in hearing threshold among the three groups before treatment(P>0.05).After treatment, the hearing threshold was significantly lower than that before treatment(P < 0.01), and the hearing threshold in group A and group B was lower than that in group C(P < 0.05).The total effective rate in group A and group B was higher than that in group C(P < 0.05), but there was no significant difference between group A and group B(P>0.05).The total adverse reaction rate in group B was significantly lower than that in group A and group C(P < 0.01).The total effective rate in group without basic disease was significantly higher than that in group with basic disease(P < 0.01).
      ConclusionsIntratympanic injection therapy is better than intravenous therapy.The type and degree of hearing loss and basic disease have great impacts on the prognosis.Therefore, it is necessary to evaluate the patient's condition in detail for taking reasonable treatment method.

       

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