范龙飞, 吴斌全, 庞青, 汪鹿瑶, 潘华东, 王春芳, 刘会春, 谈燚. ALBI和PALBI分级在乙肝相关性肝细胞癌病人预后评估中的价值[J]. 蚌埠医学院学报, 2023, 48(3): 330-334. DOI: 10.13898/j.cnki.issn.1000-2200.2023.03.012
    引用本文: 范龙飞, 吴斌全, 庞青, 汪鹿瑶, 潘华东, 王春芳, 刘会春, 谈燚. ALBI和PALBI分级在乙肝相关性肝细胞癌病人预后评估中的价值[J]. 蚌埠医学院学报, 2023, 48(3): 330-334. DOI: 10.13898/j.cnki.issn.1000-2200.2023.03.012
    FAN Long-fei, WU Bin-quan, PANG Qing, WANG Lu-yao, PANG Hua-dong, WANG Chun-fang, LIU Hui-chun, TAN Yi. The value of ALBI and PALBI grades in the prognostic assessment of hepatitis B virus associated HCC patients[J]. Journal of Bengbu Medical College, 2023, 48(3): 330-334. DOI: 10.13898/j.cnki.issn.1000-2200.2023.03.012
    Citation: FAN Long-fei, WU Bin-quan, PANG Qing, WANG Lu-yao, PANG Hua-dong, WANG Chun-fang, LIU Hui-chun, TAN Yi. The value of ALBI and PALBI grades in the prognostic assessment of hepatitis B virus associated HCC patients[J]. Journal of Bengbu Medical College, 2023, 48(3): 330-334. DOI: 10.13898/j.cnki.issn.1000-2200.2023.03.012

    ALBI和PALBI分级在乙肝相关性肝细胞癌病人预后评估中的价值

    The value of ALBI and PALBI grades in the prognostic assessment of hepatitis B virus associated HCC patients

    • 摘要:
      目的探讨白蛋白-胆红素(ALBI)和血小板-白蛋白-胆红素(PALBI)分级在Child-Pugh A级肝细胞癌(HCC)病人预后评估中的价值。
      方法行根治性手术的Child-Pugh A级乙肝相关性HCC病人134例,根据术前血清学检查结果计算ALBI和PALBI分级,采用Kaplan-Meier曲线和Cox回归分析评估病人总生存期(OS)和无复发生存期(RFS)。
      结果经随访,病死37例,复发35例。Kaplan-Meier分析结果显示,ALBI、PALBI分级与OS和RFS均具有相关关系(P < 0.05)。多因素分析显示,ALBI和PALBI分级均为病人独立的预后模型。不同评分系统间,PLABI+肿瘤直径、ALBI+肿瘤直径、ALBI+意大利肝癌小组评分(CLIP)较单独的CLIP、PLABI、ALBI、终末期肝癌模型评分、巴塞罗那分期在预后预测能力方面更具有意义。
      结论ALBI和PALBI分级是评估Child-Pugh A级HCC病人预后有价值的模型,如结合肿瘤直径,PALBI较ALBI分级有更好的预后价值。

       

      Abstract:
      ObjectiveTo explore the value of albumin-bilirubin (ALBI) and platelet-albumin-bilirubin (PALBI) grades in the prognostic evaluation of Child-Pugh grade A HCC patients.
      MethodsClinical data of 134 Child-Pugh grade A hepatitis B virus associated HCC patients undergoing radical resection were retrospectively analyzed.ALBI and PALBI grades were calculated based on preoperative serologic examination.Overall survival (OS) and recurrence-free survival (RFS) were estimated using Kaplan-Meier curves and Cox regression.
      ResultsAfter follow-up, 37 patients died and 35 patients relapsed.Kaplan-Meier analysis showed that ALBI and PALBI grades were significantly correlated with OS and RFS (P < 0.05).Multivariate analysis indicated that both ALBI and PALBI grades were independent prognostic models for patients.Among different scoring systems, PLABI + tumor diameter, ALBI + tumor diameter, and ALBI + Italian liver cancer group score (CLIP) were more significant in predicting prognosis than CLIP, PLABI, ALBI, end-stage liver cancer model score, and Barcelona staging alone.
      ConclusionsALBI and PALBI grades are valuable models for evaluating the prognosis of Child-Pugh grade A HCC patients, if when they combine with tumor diameter, PALBI grade has better prognostic value for HCC patients than ALBI grade.

       

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