Abstract:
ObjectiveTo investigate the correlation between different concomitant types of cerebral small vessel disease and vascular cognitive dysfunction.
MethodsA total of 96 outpatients and inpatients with cerebrovascular disease were selected as the observation group, while 90 normal subjects with normal cognitive function and imaging examination were selected as the control group.After enrollment, all subjects were subjected to GE Signa 3.0T EXCITE HDMR system for head MRI scan+DWI+SWI+MRA, and the films were read by two MRI specialists at the associate chief physician level.According to the results of the head MRI, the subjects were divided into single type of cerebral small vessel disease group, two types of cerebral small vessel disease group, three types of cerebral small vessel disease group, four types of cerebral small vessel disease group and normal control group.Neurological evaluation was performed on the patients using the Montrel cognitive assessment(MoCA) and the mini mental state examination(MMSE).The levels of MoCA and MMSE in different subjects were compared, and the correlation between the complexity of cerebral small vessel disease and MoCA and MMSE was analyzed.
ResultsThe levels of MoCA and MMSE in the observation group were significantly lower than those in the control group(P < 0.01).The differences of MoCA and MMSE scores in patients with different types of cerebral small vessel disease were statistically significant(P < 0.01).The scores of MoCA and MMSE were as follows: single cerebral small vessel disease group>two types of cerebral small vessel disease group >three types of cerebral small vessel disease group >four types of cerebral small vessel disease group(P < 0.05).Correlation analysis showed that the complexity of cerebral small vessel disease was negatively correlated with MoCA and MMSE(P < 0.01).
ConclusionsThe vascular cognitive dysfunction in patients with cerebral small blood vessel disease is significantly higher than that in healthy people, and the vascular cognitive impairment is more serious with the complexity of cerebral small vessel disease.