钱燕青, 冯莉. 结直肠癌膳食及相关因素的病例对照研究[J]. 蚌埠医学院学报, 2023, 48(8): 1111-1114. DOI: 10.13898/j.cnki.issn.1000-2200.2023.08.021
    引用本文: 钱燕青, 冯莉. 结直肠癌膳食及相关因素的病例对照研究[J]. 蚌埠医学院学报, 2023, 48(8): 1111-1114. DOI: 10.13898/j.cnki.issn.1000-2200.2023.08.021
    QIAN Yan-qing, FENG Li. A case-control study of correlation between diet and colorectal cancer[J]. Journal of Bengbu Medical College, 2023, 48(8): 1111-1114. DOI: 10.13898/j.cnki.issn.1000-2200.2023.08.021
    Citation: QIAN Yan-qing, FENG Li. A case-control study of correlation between diet and colorectal cancer[J]. Journal of Bengbu Medical College, 2023, 48(8): 1111-1114. DOI: 10.13898/j.cnki.issn.1000-2200.2023.08.021

    结直肠癌膳食及相关因素的病例对照研究

    A case-control study of correlation between diet and colorectal cancer

    • 摘要:
      目的分析结直肠癌发生的膳食危险因素和保护因素, 为结直肠癌预防提供依据。
      方法运用病例对照研究方法, 选择复旦大学附属闵行医院2021年1-3月新发结直肠癌病人55例为观察组, 同时选择与之在年龄、性别、地区相匹配的同期住院非结直肠癌病人96例为对照组, 采用食物频率调查问卷, 对调查对象进行面对面问卷调查, 采用非参数检验、χ2检验进行单因素分析, 条件logistics回归进行多因素分析。
      结果单因素分析结果显示, 动物内脏、深色蔬菜、菌菇类、鲜奶、酸奶、牛肉、禽肉、坚果、泡菜腌渍食品、蛋类、文化程度、职业与结直肠癌相关; logistics回归分析结果显示, 动物内脏(OR=3.471, 95%CI: 1.395~8.634)增加结直肠癌发病风险; 深色蔬菜(OR=0.131, 95%CI: 0.036~0.482)、菌菇类(OR=0.245, 95%CI: 0.083~0.726)、鲜奶(OR=0.243, 95%CI: 0.085~0.696)、蛋类(OR=0.221, 95%CI: 0.086~0.570)降低结直肠癌发病风险。
      结论动物内脏为结直肠癌的危险因素; 深色蔬菜、菌菇类、禽类、蛋类为结直肠癌的保护因素。

       

      Abstract:
      ObjectiveTo analyze the dietary risk factors and protective factors for the occurrence of colorectal cancer, and to provide the basis for the prevention of colorectal cancer.
      MethodsA case-control study was conducted with 55 newly diagnosed colorectal cancer patients from Minhang Hospital Affiliated to Fudan University from January to March 2021 as the case group.Simultaneously, 96 non-colorectal cancer patients matched for age, gender, and region during the same period were selected as the control group.A food frequency questionnaire was utilized for face-to-face surveys of the subjects, with single factor analysis conducted using non-parametric tests and χ2 tests, and multi-factor analysis via conditional logistic regression.
      ResultsSingle factor analysis results indicated a correlation between colorectal cancer and factors such as animal offal, dark vegetables, fungi, fresh milk, yogurt, beef, poultry, nuts, pickled foods, eggs, educational level, and occupation.Logistic regression analysis results revealed that animal offal (OR=3.471, 95%CI: 1.395-8.634) increased the risk of colorectal cancer, while dark vegetables (OR=0.131, 95%CI: 0.036-0.482), fungi (OR=0.245, 95%CI: 0.083-0.726), fresh milk (OR=0.243, 95%CI: 0.085-0.696), and eggs (OR=0.221, 95%CI: 0.086-0.570) decreased the risk.
      ConclusionsAnimal offal is a risk factor for colorectal cancer, while dark vegetables, fungi, poultry, and eggs serve as protective factors.

       

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