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    孙军培, 杜丹丽, 张燕, 杨晓东, 李雪婷, 丁彪, 张枫, 刘雷, 王学故, 宫莹莹. 减重对肥胖病人精液质量及生殖激素的影响[J]. 蚌埠医科大学学报, 2023, 48(9): 1199-1202. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.004
    引用本文: 孙军培, 杜丹丽, 张燕, 杨晓东, 李雪婷, 丁彪, 张枫, 刘雷, 王学故, 宫莹莹. 减重对肥胖病人精液质量及生殖激素的影响[J]. 蚌埠医科大学学报, 2023, 48(9): 1199-1202. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.004
    shu
    SUN Jun-pei, DU Dan-li, ZHANG Yan, YANG Xiao-dong, LI Xue-ting, DING Biao, ZHANG Feng, LIU Lei, WANG Xue-gu, GONG Ying-ying. Effect of weight loss on semen quality and reproductive hormones in obese patients[J]. Journal of Bengbu Medical University, 2023, 48(9): 1199-1202. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.004
    Citation: SUN Jun-pei, DU Dan-li, ZHANG Yan, YANG Xiao-dong, LI Xue-ting, DING Biao, ZHANG Feng, LIU Lei, WANG Xue-gu, GONG Ying-ying. Effect of weight loss on semen quality and reproductive hormones in obese patients[J]. Journal of Bengbu Medical University, 2023, 48(9): 1199-1202. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.004
    shu

    减重对肥胖病人精液质量及生殖激素的影响

    Effect of weight loss on semen quality and reproductive hormones in obese patients

      摘要
    • 摘要:
      目的探讨肥胖病人减重对精子质量和生殖激素的影响。
      方法30例肥胖病人体质量指数(BMI)28.2~45.37 kg/m2进行为期14周的减重计划。对病人减重前后的精液样本及血液样本进行检测。使用计算机辅助精子分析系统检测精子常规指标精液体积、精子浓度、总精子数量、前向运动精子率(PR)、精子总活力、精子正常形态率；使用染色质结构分析法分析精子DNA碎片指数(DFI)；使用罗氏性激素分析仪测定血液中相关激素指标睾酮(T)、雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)、抗缪勒管激素(AMH)。
      结果减重前，随着病人BMI的升高，精子浓度、精子总数、AMH及T的数值降低(P<0.01)，而精子DFI及E2的数值增加(P<0.01)。减重后，精子浓度、总精子数量、PR、精子总活力、AMH及T较减重前增加(P<0.05~P<0.01)；精液体积及精子DFI较减重前减少(P<0.05和P<0.01)，FSH、LH及E2较减重前差异均无统计学意义(P>0.05)。
      结论肥胖与精液质量差和生殖激素水平的改变有关。减重可能会导致精子质量的改善。

       

      Abstract:
      ObjectiveTo observe the effect of weight loss on sperm quality and reproductive hormones in obese patients.
      MethodsThirty obese patients with a body mass index (BMI) of 28.2-45.37 kg/m2 underwent a 14 weeks weight loss plan.Semen and blood samples from patients were tested before and after weight loss.Routine sperm indicators semen volume, sperm concentration, total sperm count, progressive motility sperm rate (PR), total sperm motility, and normal sperm morphology rate were detected using the computer assisted sperm analysis system.Sperm DNA fragmentation index (DFI) was analyzed using sperm chromatin structure assay (SCSA).Relevant hormone indicators in the blood testosterone (T), estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), and anti-Müllerian hormone (AMH) were measured using a Roche sex hormone analyzer.
      ResultsBefore weight loss, as the patient's BMI increased, the values of sperm concentration, total sperm count, AMH, and T decreased (P<0.01), while the values of sperm DFI and E2 increased (P<0.01).After weight loss, the sperm concentration, total sperm count, progressive motility sperm rate, total sperm motility, AMH and T increased compared to before weight loss (P<0.05 to P<0.01).semen volume and sperm DFI decreased compared to before weight loss (P<0.05 and P<0.01), FSH, LH, and E2 showed no statistically significant differences compared to before weight loss (P>0.05).
      ConclusionsObesity is related to poor semen quality and changes in reproductive hormone levels.Weight loss may lead to an improvement in sperm quality.

       

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