ObjectiveTo explore the value of the detection of serum thyroglobulin combined with thyroglobulin antibody in predicting the prognosis of patients with thyroid cancer.

MethodsOne hundred and eighty patients treated with thyroid cancer surgery were selected, and followed up for 2 years after surgery.According to the following-up results, the patients were divided into the good prognosis group(141 cases) and poor prognosis group(39 cases), and the clinicopathological characteristics(lymph node metastasis and primary focus) after surgery and preoperative thyroid hormone, thyrotropin, thyroglobulin, anti-thyroid autoantibodies and other thyroid function related indicators were compared between two groups.The multivariate logistic regression model analysis was used to analyze the prognostic factors, and the ROC curve was used to analyze the clinical predictive value of prognostic indicators.

ResultsThe proportions of stage T₃/T₄ of primary focus and multiple lymph node metastasi, and serum levels of thyrotropin, thyroglobulin and thyroglobulin antibody in the poor prognosis group were higher than those in good prognosis group(P < 0.05 to P < 0.01).The results of multivariate logistic regression analysis showed that the high thyroglobulin, high thyrotropin, high anti-thyroid autoantibodies, stage T₃/T₄ of primary focus and multiple lymph node metastasis were the independent risk factors of the prognosis of patients (P < 0.01).The results of ROC curve analysis showed that the AUC of serum thyroglobulin, thyroglobulin antibody, thyrotropin and their combination in predicting the prognosis of patients were 0.878, 0.831, 0.811 and 0.978, respectively, and the combined prediction value of three indexes was higher than that of single index (P < 0.01).

ConclusionsThe detection of thyroglobulin, thyroglobulin antibody combined with thyrotropin have good prognostic value in differentiated thyroid cancer patients.