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    刘飞, 李东戈, 刘娟, 张辉, 涂胜. 血清NT-proBNP联合D-二聚体对ACS病人急诊PCI术后无复流的诊断价值[J]. 蚌埠医科大学学报, 2023, 48(9): 1223-1226. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.010
    引用本文: 刘飞, 李东戈, 刘娟, 张辉, 涂胜. 血清NT-proBNP联合D-二聚体对ACS病人急诊PCI术后无复流的诊断价值[J]. 蚌埠医科大学学报, 2023, 48(9): 1223-1226. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.010
    shu
    LIU Fei, LI Dong-ge, LIU Juan, ZHANG Hui, TU Sheng. Diagnostic value of serum NT-proBNP combined with D-dimer in patients with ACS without reflow after emergency PCI[J]. Journal of Bengbu Medical University, 2023, 48(9): 1223-1226. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.010
    Citation: LIU Fei, LI Dong-ge, LIU Juan, ZHANG Hui, TU Sheng. Diagnostic value of serum NT-proBNP combined with D-dimer in patients with ACS without reflow after emergency PCI[J]. Journal of Bengbu Medical University, 2023, 48(9): 1223-1226. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.010
    shu

    血清NT-proBNP联合D-二聚体对ACS病人急诊PCI术后无复流的诊断价值

    Diagnostic value of serum NT-proBNP combined with D-dimer in patients with ACS without reflow after emergency PCI

      摘要
    • 摘要:
      目的探讨N末端B型利钠肽原(NT-proBNP)联合D-二聚体对急性冠状动脉综合征(ACS)病人急诊经皮冠状动脉介入治疗(PCI)术后无复流发生的预测价值。
      方法选择接受急诊PCI的ACS病人80例，根据是否正常复流，将PCI术后病人分为无复流组39例和正常复流组41例。于PCI术前检测2组病人血清NT-proBNP和D-二聚体水平，采用ROC曲线评价NT-proBNP和D-二聚体对无复流的预测价值，采用logistic回归模型分析无复流的影响因素。
      结果无复流组病人NT-proBNP和D-二聚体水平均高于正常复流组(P < 0.01和P < 0.05)；logistic回归分析显示，糖尿病、急诊室至血管开通时间长、高D-二聚体和NT-proBNP水平均为无复流的独立危险因素(P < 0.05~P < 0.01)。ROC曲线分析显示，NT-proBNP联合D-二聚体预测无复流AUC值为0.852，敏感度和特异度分别为85.6%和70.9%。
      结论PCI术前NT-proBNP联合D-二聚体预测ACS病人PCI术后无复流具有一定临床价值。

       

      Abstract:
      ObjectiveTo investigate the role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) combined with D-dimer in predicting the occurrence of no-reflow in patients with acute coronary syndrome (ACS) after emergency emergency percutaneous coronary intervention (PCI).
      MethodsEighty ACS patients who underwent emergency PCI were selected as the research subjects.Among them, 39 cases had no-reflow after PCI, and 41 had normal reflow.The levels of serum NT-proBNP and D-dimer in the patients were detected before PCI.The ROC curves were used to evaluate the predictive value of NT-proBNP and D-dimer for no-reflow.Logistic regression model was used to analyze the independent influencing factors of no-reflow.
      ResultsThe levels of NT-proBNP and D-dimer in patients without reflow were significantly higher than those in patients with normal reflow (P < 0.01 and P < 0.05).Logistic regression analysis showed that diabetes, longer time from emergency room to vascular patency, high levels of D-dimer and NT-proBNP were all independent risk factors of no-reflow (P < 0.05 to P < 0.01).ROC curve analysis showed that the AUC value of NT-proBNP combined with D-dimer was 0.852, and the sensitivity and specificity were 85.6% and 70.9%, respectively.
      ConclusionsPreoperative NT-proBNP combined with D-dimer has a certain clinical value in predicting the occurrence of no-reflow after PCI in patients with ACS.

       

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