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    邵丽娜, 王传珍, 谢凤云. 血清LDH、UA、钙离子水平预测妊娠期高血压不良孕产结局的效能探讨[J]. 蚌埠医科大学学报, 2023, 48(9): 1240-1244. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.014
    引用本文: 邵丽娜, 王传珍, 谢凤云. 血清LDH、UA、钙离子水平预测妊娠期高血压不良孕产结局的效能探讨[J]. 蚌埠医科大学学报, 2023, 48(9): 1240-1244. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.014
    shu
    SHAO Li-na, WANG Chuan-zhen, XIE Feng-yun. Study on the predictive value of serum levels of LDH, UA and calcium ion in the adverse pregnancy outcomes in patients with pregnancy-induced hypertension[J]. Journal of Bengbu Medical University, 2023, 48(9): 1240-1244. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.014
    Citation: SHAO Li-na, WANG Chuan-zhen, XIE Feng-yun. Study on the predictive value of serum levels of LDH, UA and calcium ion in the adverse pregnancy outcomes in patients with pregnancy-induced hypertension[J]. Journal of Bengbu Medical University, 2023, 48(9): 1240-1244. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.014
    shu

    血清LDH、UA、钙离子水平预测妊娠期高血压不良孕产结局的效能探讨

    Study on the predictive value of serum levels of LDH, UA and calcium ion in the adverse pregnancy outcomes in patients with pregnancy-induced hypertension

      摘要
    • 摘要:
      目的探讨血清乳酸脱氢酶(LDH)、尿酸(UA)、钙离子水平对妊娠期高血压病人孕产结局不良的预测价值。
      方法选取妊娠期高血压病人112例作为观察组，另选取同期接诊的健康孕妇120例作为对照组。比较2组血清LDH、UA和钙离子水平以及母体和围生儿不良结局发生率；比较观察组病人中母体和围产儿结局不良者与良好者血清LDH、UA和钙离子水平；采用logistic回归模型分析妊娠期高血压母体和围生儿不良结局的影响因素；采用ROC曲线分析血清LDH、UA、钙离子水平对妊娠期高血压母体和围生儿不良结局的预测效能。
      结果观察组血清LDH、UA水平均明显高于对照组(P < 0.01)，钙离子水平明显低于对照组(P < 0.01)；观察组母体和围生儿不良结局发生率均明显高于对照组(P < 0.01)。观察组母体及围生儿不良结局者年龄和血清LDH、UA水平均高于良好结局者(P < 0.05~P < 0.01)，钙离子水平低于良好结局者(P < 0.05)；logistic回归模型分析显示，校正年龄后，血清LDH、UA水平升高和钙离子水平降低均为妊娠期高血压病人母体及围生儿不良结局的独立危险因素(P < 0.01)。血清LDH、UA联合钙离子水平对妊娠期高血压病人母体和围生儿不良结局的预测灵敏度和ROC曲线下面积均高于单独预测。
      结论妊娠期高血压病人血清LDH、UA升高，钙离子水平降低，三者均为妊娠期高血压病人不良孕产结局的独立影响因素，三者联合预测不良孕产结局的效能较好。

       

      Abstract:
      ObjectiveTo explore the predictive value of serum lactate dehydrogenase(LDH), uric acid(UA) and calcium ion levels in the adverse pregnancy outcomes in patients with pregnancy-induced hypertension.
      MethodsOne hundred and twenty patients with pregnency-induce hypertension were selected as the observation group, and 120 healthy pregnant women in the same period were selected as the control group.The levels of serum LDH, UA and calcium ion, and incidence rates of adverse outcomes in maternal and perinatal infants were compared between two groups.The levels of serum LDH, UA and calcium ion in patients with poor maternal and perinatal outcomes were compared with those with good outcomes in observation group.Logistic regression model was used to analyze the influencing factors of adverse outcomes of maternal and perinatal infants with pregnency-induce hypertension, and the receiver operating characteristic ROC (curve) was used to analyze the predictive efficacy of the serum LDH, UA and calcium ion levels in maternal and perinatal adverse outcomes of patients with pregnency-induce hypertension.
      ResultsThe serum levels of LDH, UA in the observation group were higher than those in control group(P < 0.01), the serum level of calcium ion in the observation group was lower than that in control group(P < 0.01), and the incidence rates of maternal and perinatal adverse outcomes in the observation group were higher than those in control group (P < 0.01).In the observation group, the age and serum levels of serum LDH and UA in patents with poor outcomes of the mother and perinatal infants were higher than those with good outcomes of maternal and perinatal infants(P < 0.05 to P < 0.01), and the level of serum calcium ion was lower than those with good outcomes of maternal and perinatal infants(P < 0.05).The resultts of logistic regression model analysis showed that after adjusting for age, the increase of serum LDH and UA levels and decrease of calcium ion level were the independent risk factors of maternal and perinatal adverse outcomes in patients with pregnency-induce hypertension(P < 0.01), and the predictive sensitivity and area under ROC curve of serum LDH, UA combined with calcium ion levels in maternal and perinatal adverse outcomes of pregnency-induce hypertension patients were higher than those predicted alone(P < 0.05).
      ConclusionsThe serum LDH and UA levels increase, and the calcium ion level decreases in patients with pregnancy-induced hypertension.All are the independent influencing factors of adverse pregnancy outcomes, and the combined detection of the three factors is better in predicting adverse pregnancy outcomes.

       

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