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    左梅, 王端乐, 辛浩, 赵娟, 张建华. 冠心病病人介入治疗围术期炎性因子变化及心肌损伤相关因素分析[J]. 蚌埠医科大学学报, 2023, 48(9): 1258-1261. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.018
    引用本文: 左梅, 王端乐, 辛浩, 赵娟, 张建华. 冠心病病人介入治疗围术期炎性因子变化及心肌损伤相关因素分析[J]. 蚌埠医科大学学报, 2023, 48(9): 1258-1261. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.018
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    ZUO Mei, WANG Duan-le, XIN Hao, ZHAO Juan, ZHANG Jian-hua. Analysis of inflammatory factor change in the perioperative period and myocardial injury-related factors in patients with coronary heart disease after intervention therapy[J]. Journal of Bengbu Medical University, 2023, 48(9): 1258-1261. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.018
    Citation: ZUO Mei, WANG Duan-le, XIN Hao, ZHAO Juan, ZHANG Jian-hua. Analysis of inflammatory factor change in the perioperative period and myocardial injury-related factors in patients with coronary heart disease after intervention therapy[J]. Journal of Bengbu Medical University, 2023, 48(9): 1258-1261. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.018
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    冠心病病人介入治疗围术期炎性因子变化及心肌损伤相关因素分析

    Analysis of inflammatory factor change in the perioperative period and myocardial injury-related factors in patients with coronary heart disease after intervention therapy

      摘要
    • 摘要:
      目的分析冠心病病人介入手术治疗后围术期炎性因子变化及导致心肌损伤的相关因素。
      方法选取行经皮冠脉介入治疗的冠心病病人65例作为研究对象，根据介入治疗后围术期是否发生心肌损伤分为心机损伤组和未发生心肌损伤组。比较2组一般资料及手术前后炎性因子水平。采用logistic回归分析术后发生心肌损伤的危险因素。
      结果2组病人手术前超敏C反应蛋白(hs-CRP)、白细胞介素-10(IL-10)、干扰素-γ(IFN-γ)差异均无统计学意义(P>0.05)；2组手术后hs-CRP、TNF-α、IL-10、IFN-γ水平均高于手术前(P < 0.05~P < 0.01)；心肌损伤组病人hs-CRP、IL-10、IFN-γ水平高于未发生心肌损伤组(P < 0.05~P < 0.01)。2组载脂蛋白B水平、年龄、高血压史、糖尿病史、吸烟史、冠心病类型、术前负荷量服用他汀药物差异均有统计学意义(P < 0.00.05~P < 0.01)。多因素logistic回归分析显示，年龄>60岁、冠心病类型不稳定型、术前负荷量服用他汀药物、载脂蛋白B水平均为术后发生心肌损伤的危险因素(P < 0.00.05)。
      结论冠心病介入治疗后病人围术期炎性因子水平升高，年龄>60岁、冠心病类型不稳定型、术前负荷量服用他汀药物均为术后发生心肌损伤的危险因素。

       

      Abstract:
      ObjectiveTo analyze the changes of inflammatory factors in the perioperative period and myocardial injury-related factors in patients with coronary heart disease after intervention therapy.
      MethodsSixty-five patients with coronary heart disease undergoing percutaneous coronary intervention were selected as the study subjects.According to myocardial injury occurrence or not in the perioperative period after intervention therapy, they were divided into the myocardial injury group and non-myocardial injury group.The general data and the levels of inflammatory factors before and after operation were compared between the two groups.Logistic regression was used to analyze the risk factors for occurrence of postoperative myocardial injury.
      ResultsThere was no significant difference in high-sensitivity C-reactive protein (hs-CRP), interleukin-10 (IL-10) and interferon-γ (IFN-γ) levels before operation between the two groups (P>0.05).The levels of hs-CRP, TNF-α, IL-10 and IFN-γ in the two groups after operation were higher than those before operation (P < 0.05 to P < 0.01), and the levels of hs-CRP, IL-10 and IFN-γ in myocardial injury group were higher than those in non-myocardial injury group (P < 0.05 to P < 0.01).There were significant differences in apolipoprotein B level, age, history of hypertension, history of diabetes mellitus, history of smoking, type of coronary heart disease, and preoperative loading dose of statins between the two groups (P < 0.05 to P < 0.01).Multivariate logistic regression analysis showed that age >60 years old, unstable coronary heart disease type, preoperative loading dose of statins, and apolipoprotein B level were the risk factors for occurrence of postoperative myocardial injury (P < 0.05).
      ConclusionsThe increased levels of inflammatory factors in patients with coronary heart disease in the perioperative period after intervention therapy, age >60 years old, unstable coronary heart disease type, and preoperative loading dose of statins are risk factors for occurrence of postoperative myocardial injury.

       

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