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    田丹丹, 王善萍, 杨丽, 张婷婷, 何丽, 刘天阳, 谌曦. 系统性红斑狼疮病人焦虑抑郁状态及其相关因素研究[J]. 蚌埠医科大学学报, 2023, 48(9): 1309-1313. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.030
    引用本文: 田丹丹, 王善萍, 杨丽, 张婷婷, 何丽, 刘天阳, 谌曦. 系统性红斑狼疮病人焦虑抑郁状态及其相关因素研究[J]. 蚌埠医科大学学报, 2023, 48(9): 1309-1313. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.030
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    TIAN Dan-dan, WANG Shan-ping, YANG Li, ZHANG Ting-ting, HE Li, LIU Tian-yang, CHEN Xi. Anxiety and depression in patients with systemic lupus erythematosus and its related factors[J]. Journal of Bengbu Medical University, 2023, 48(9): 1309-1313. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.030
    Citation: TIAN Dan-dan, WANG Shan-ping, YANG Li, ZHANG Ting-ting, HE Li, LIU Tian-yang, CHEN Xi. Anxiety and depression in patients with systemic lupus erythematosus and its related factors[J]. Journal of Bengbu Medical University, 2023, 48(9): 1309-1313. DOI: 10.13898/j.cnki.issn.1000-2200.2023.09.030
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    系统性红斑狼疮病人焦虑抑郁状态及其相关因素研究

    Anxiety and depression in patients with systemic lupus erythematosus and its related factors

      摘要
    • 摘要:
      目的探究系统性红斑狼疮(SLE)病人焦虑抑郁情况及其相关因素。
      方法收集202例SLE病人社会人口学资料和评估疾病活动指标，采用焦虑自评量表(SAS)和抑郁自评量表(SDS)评定病人焦虑、抑郁状态，采用单因素、关联规则分析、logistic回归分析焦虑、抑郁和焦虑合并抑郁相关影响因素。
      结果202例SLE病人中抑郁发生率43.56%(88/202)，焦虑发生率为47.53%(96/202)，焦虑合并抑郁发生率为37.13%(75/202)。单因素分析显示，焦虑组医保类型、婚姻状况、年收入情况、就业情况、生育情况、匹兹堡睡眠指数评分(PSQI)是其相关因素(P<0.05~P<0.01)；抑郁组医保类型、SLE疾病活动指数(SLEDAI)、PSQI是其相关因素(P<0.01)；焦虑合并抑郁组病程、教育程度、医保类型、生育情况、SLEDAI、PSQI是其相关因素(P<0.05~P<0.01)。logistic回归分析结果示SLEDAI、PSQI、医保类型是焦虑合并抑郁的独立危险因素(P<0.05~P<0.01)。其中医保类型是最大危险因素(OR=3.720，P<0.01)。关联规则分析显示，焦虑抑郁状态的发生与SLE病人SLEDAI、PSQI有明显关联。
      结论SLE病人容易出现焦虑抑郁状态，与经济状况、疾病活动等因素密切相关。

       

      Abstract:
      ObjectiveTo study anxiety and depression in patients with systemic lupus erythematosus (SLE) and its related factors.
      MethodsSocial demographic data and disease activity indicators were collected from 202 patients with SLE.Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) were used to evaluate anxiety and depression.Univariate, association rule analysis and logistic regression were used to analyze the related influencing factors of anxiety, depression and anxiety combined with depression.
      ResultsAmong 202 patients with SLE, the incidence of depression was 43.56% (88/202), the incidence of anxiety was 47.53% (96/202) and the incidence of anxiety combined with depression was 37.13% (75/202).Univariate analysis showed that the medical insurance type, marital status, annual income, employment status, fertility status and Pittsburgh Sleep Quality Index (PSQI) were related factors in the anxious group (P<0.05 to P<0.01), the medical insurance type, systemic lupus erythematosus disease activity index (SLEDAI) and PSQI were related factors in the depression group (P<0.01), while the disease course, education level, medical insurance type, fertility status, SLEDAI, and PSQI were the related factors in the anxiety combined with depression group (P<0.05 to P<0.01).Logistic regression analysis showed that the SLEDAI, PSQI and medical insurance types were independent risk factors for anxiety combined with depression (P<0.05 to P<0.01), among them, the type of medical insurance was the biggest risk factor (OR=3.720, P<0.01).Association rule analysis showed that the incidence of anxiety and depression was significantly associated with SLEDAI and PSQI in SLE patients.
      ConclusionsSLE patients are prone to anxiety and depression, which is closely related to economic status, disease activity and other factors.

       

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