李利峰, 霍旭宁, 路峰, 黄津, 刘秀君. 清晨血压与非致残性急性缺血性脑卒中病人神经功能及动脉弹性的相关性研究[J]. 蚌埠医学院学报, 2023, 48(10): 1398-1402. DOI: 10.13898/j.cnki.issn.1000-2200.2023.10.016
    引用本文: 李利峰, 霍旭宁, 路峰, 黄津, 刘秀君. 清晨血压与非致残性急性缺血性脑卒中病人神经功能及动脉弹性的相关性研究[J]. 蚌埠医学院学报, 2023, 48(10): 1398-1402. DOI: 10.13898/j.cnki.issn.1000-2200.2023.10.016
    LI Li-feng, HUO Xu-ning, LU Feng, HUANG Jin, LIU Xiu-jun. Relationship between early morning blood pressure and neurological function and arterial elasticity in patients with non-disabling acute ischemic stroke[J]. Journal of Bengbu Medical College, 2023, 48(10): 1398-1402. DOI: 10.13898/j.cnki.issn.1000-2200.2023.10.016
    Citation: LI Li-feng, HUO Xu-ning, LU Feng, HUANG Jin, LIU Xiu-jun. Relationship between early morning blood pressure and neurological function and arterial elasticity in patients with non-disabling acute ischemic stroke[J]. Journal of Bengbu Medical College, 2023, 48(10): 1398-1402. DOI: 10.13898/j.cnki.issn.1000-2200.2023.10.016

    清晨血压与非致残性急性缺血性脑卒中病人神经功能及动脉弹性的相关性研究

    Relationship between early morning blood pressure and neurological function and arterial elasticity in patients with non-disabling acute ischemic stroke

    • 摘要:
      目的探讨分析清晨血压与非致残性急性缺血性脑卒中病人神经功能及动脉弹性之间的相关性。
      方法选取126例急性非致残性缺血性脑卒中病人作为研究对象,另选取同期健康体检的100名健康体检者作为对照组。检测并比较2组病人清晨血压、动脉弹性指标及神经功能评分,分析清晨血压与动脉弹性、神经功能的相关性。
      结果病例组病人清晨收缩压和舒张压均高于对照组(P < 0.01),动脉弹性指标颈-桡动脉脉搏波传导速度(CrPWV)、颈动脉内膜中层厚度(IMT)和僵硬度指数β均明显高于对照组(P < 0.01),美国国立卫生研究所脑卒中量表(NIHSS)评分也明显高于对照组(P < 0.01)。病例组病人根据清晨收缩压和舒张压水平将其分为低水平组、中水平组和高水平组,血压水平越高,CrPWV、IMT、僵硬度指数β和NIHSS评分越高(P < 0.01)。相关性分析显示,清晨血压水平与CrPWV、IMT、僵硬度指数β和NIHSS评分均呈正相关关系(P < 0.01)。多元线性回归分析显示年龄、清晨收缩压是CrPWV的独立影响因素(P < 0.01和P < 0.05),LDL-C和清晨收缩压是IMT的独立影响因素(P < 0.01),年龄、BMI、清晨收缩压、清晨舒张压均是僵硬度指数β和NIHSS评分的独立影响因素(P < 0.05~P < 0.01)。
      结论清晨血压与非致残性急性缺血性脑卒中病人神经功能缺损程度和动脉弹性相关。

       

      Abstract:
      ObjectiveTo investigate the relationship between early morning blood pressure and neurological function and arterial elasticity in patients with non-disabling acute ischemic stroke.
      MethodsA total of 126 patients with acute non-disabling ischemic stroke were selected as the research object, and 100 healthy people who had physical examination during the same period were selected as the control group.Blood pressure, arterial elasticity index and neurological function score were detected and compared between the two groups, and the correlation between early morning blood pressure and arterial elasticity and neurological function was analyzed.
      ResultsThe mean systolic blood pressure and mean diastolic blood pressure in the morning in the case group were significantly higher than those in the control group (P < 0.01).The indexes of arterial elasticity, such as carotid radial pulse wave velocity (CrPWV), carotid intima-media thickness (IMT) and stiffness index β were significantly higher than those in the control group (P < 0.01).NIHSS score was also significantly higher than that of the control group (P < 0.01).According to the early morning systolic and diastolic blood pressure levels, the patients in the case group were divided into low-level group, medium-level group and high-level group.The differences of CrPWV, IMT, stiffness index β and NIHSS score of each group were statistically significant (P < 0.01).Correlation analysis showed that early morning blood pressure level was significantly positively correlated with CrPWV, IMT, stiffness index β and NIHSS score (P < 0.01).Multiple linear regression analysis showed that age and early morning systolic blood pressure were the independent influencing factors for CrPWV (P < 0.01 and P < 0.05);LDL-C and early morning systolic blood pressure were the independent influencing factors for IMT (P < 0.01);age, BMI, early morning systolic blood pressure and morning diastolic blood pressure were independent influencing factors for stiffness index β and WIHSS score (P < 0.05 to P < 0.01).
      ConclusionsEarly morning blood pressure is related to the degree of neurological impairment and arterial elasticity in patients with non-disabling acute ischemic stroke.

       

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