Abstract: Objective: To study the clinical effect of ferrous gluconate on children with recurrent respiratory tract infections(RRTI).Methods: One hundred and eight children with RRTI and iron deficiency anemia(IDA) were divided into two groups.The observation group were given ferrous gluconate on the basis of routine therapy and the control group were treated by routine therapy.Serum specimens were collected before and after the treatment.IgG,IgA,IgM were determined by scattered nephelometry and the curative effect was evaluated.Results: The levels of serum IgG,IgA in the observation group were higher than that of the controls(P<0.001).The response rate in the observation group was higher than that in the control group(71.19% vs 32.35%)(P<0.005).Conclusions: Iron deficiency is highly related to the development of RRTI in children.To determine the iron concentration and to replenish iron preparation is beneifcial to the treatment of children with RRTI.