Abstract: Objective:To explore of the effects of L-carnitine(LC) in the treatment of nonalcoholic fatty liver disease(NAFLD).Methods:Sixty-two patients with NAFLD were randomly divided into the LC treatment group(LC group)(32 cases) and placebo control group(30 cases). The LC group were treated with 1 g of LC by oral,twice a day for 24 weeks after breakfast and dinner. The levels of serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),-glutamyltransferase(GGT),triglyceride(TG),total cholesterol(TC),C reactive protein(CRP),fasting plasma glucose(FBG),insulin(FINS),insulin resistance index(HOMA-IR) and liver ultrasound in all patients were recorded before and after treatment.Results:Compared with the before treatment and control group,the levels of ALT,AST and GGT,TG and the TC,FINS and HOMA-IR of LC group decreased significantly(P0.01),and the liver B ultrasound was improved obviously after treatment. The total effective rate of the LC group was significantly higher than that in control group(P0.01).Conclusions:L-carnitine can effectively improve the liver function and blood lipid,and reduce the insulin resistance of patients with NAFLD,which is a safe and effective drug in the treatment of NAFLD.