Abstract: Objective:To investigate the factors affecting the survival prognosis of patients with ovarian serous carcinoma.Methods:Fifty-four patients with ovarian serous carcinoma were included in the study.The age,clinical manifestation,clinical stage and additional tests of the patients were analyzed.All the patients underwent surgical treatment.Forty-one early-stage cases were performed staging surgeries and 13 advanced cases cytoreductive surgeries.All of them received postoperative adjuvant chemotherapy.Thirty-eight cases received not less than 6 courses of chemotherapy and 16 cases less than 6 courses.Results:The peak age of onset was between 50 and 59,and the most common symptoms were abdominal pain(43 cases),vaginal bleeding(7 cases),abdominal distension(35 cases) and palpable abdominal mass(15 cases).Miss-diagnosis often occurred in intraoperative frozen and it was difficult to make a diagnosis by a single auxiliary examination,so combined examination was necessary.The survival rate of the patients having received not less than 6 courses of postoperative chemotherapy was high than that of patients having received less than 6 courses(P0.05).Conclusions:The screening of ovarian cancer should use a comprehensive analysis combining the detection of tumor markers,symptoms,physical signs and imaging;It is particularly important to improve the accuracy of intraoperative frozen;Effective cytoreductive surgery is essential;The patients should be assured to receive not less than 6 courses of postoperative chemotherapy.