Abstract: Objective:To investigate the clinical effect of limited fluid infusion in treatment of cirrhosis patients with massive upper gastrointestinal hemorrhage.Methods:One hundred and nine cirrhosis patients with massive upper gastrointestinal hemorrhage were randomly divided into limited fluid infusion group(53 cases) and limited fluid infusion group(56 cases),and each group was given limited fluid infusion or common fluid infusion as well as therapies for restraining the gastric acid,hematischesis and lowering the portal venous pressure.The hematischesis time,complication and mortality rate were compared between the two groups.Results:The average hemostasis time of limited fluid infusion group was obviously less than that of the control group(P0.01).In limited fluid infusion group,only 2 patients presented mild hepatic encephalopathy and no one died;however,in the control group,3 patients had hepatic encephalopathy,13 were complicated with ascites,4 presented oliguria or anuria,1 was complicated with spontaneous peritonitis and 14 died.The complication and fatality rates had statistical difference between the two groups(P0.01).Conclusions:Limited fluid infusion is advantageous for cirrhosis patients combined with massive upper gastrointestinal hemorrhage.It may reduce the incidence of ascites,hepatic encephalopathy and hepatorenal syndrome,eventually decreasing the fatality rate.