门静脉高压断流术后血小板计数变化与肝功能的关系

孙强; 郑正

门静脉高压断流术后血小板计数变化与肝功能的关系

孙强,
郑正

The relationship between the blood platelet count and liver function after disconnection in patient with portal hypertension

摘要

摘要: 目的：探讨肝硬化门静脉高压患者脾切除联合断流术后血小板计数(BPC)变化与肝功能的关系。方法：对106例脾切除联合断流术患者的临床资料进行回顾分析，比较术前肝功能Child-Pugh A、B、C级患者术后BPC的变化。结果：术后2周肝功能A级组患者BPC高于B级组和C级组(P0.05和P0.01)；肝功能好转患者术后BPC较术前明显升高(P0.01)，肝功能恶化患者手术前后BPC差异无统计学意义(P0.05)，肝功能好转患者手术前后BPC变化明显高于肝功能恶化者(P0.01)。结论：肝硬化门静脉高压患者血小板数量较少除与脾功能亢进有关外，还可能与肝功能变化有关。

Abstract: Objective:To investigate the relationship between the blood platelet count(BPC) and liver function after splenectomy and disconnection in patient with portal hypertension.Methods:The clinical data of 106 patients treated with splenectomy and disconnection were retrospectively analyzed，the BPC of patient with grade A，B and C liver function were compared before and after operation.Results:The BPC in patients with grade A liver function were higher than that in patients with grade B and C liver function in 2 weeks after operation(P0.05 and P0.01).The BPC in patients with the improvement of liver function after operation were significantly higher than that before operation(P0.01).The differences of BPC in patients with the deterioration of liver function before and after operation had nostatistical significance(P0.05).The difference of BPC before and after operation in patients with the improvement of liver function was significantly higher than that in patients with the deterioration of liver function(P0.01).Conclusions:The decreasing BPC in patient with portal hypertension is related to hypersplenism and liver function.

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