Abstract: Objective: To investigate the nursing intervention in the bronchoscope needle aspiration biopsy (TBNA) complication function.Method: has given the whole course nursing intervention of pulmonary, mediastinal lesions underwent TBNA examination in 46 cases, including preoperative preparation, psychological nursing, medicine and equipment preparation, intraoperative cooperation and postoperative nursing. 1D before discharge nursing satisfaction survey.Results:46 patients for lung cancer in 37 cases, 9 cases of benign lesions. Hemoptysis occurred only in 2 patients, 1 patients with left pneumothorax (left lung compression 10%), after bed rest and oxygen, the left lung reexpansion completely. Clinical nursing satisfaction is very satisfactory in 37 cases, good in 9 cases, the total effective rate was 100%.Conclusion:TBNA operation for pulmonary, mediastinal lesions in patients with qualitative diagnosis is simple, minimally invasive, good safety, high accuracy advantages. Through the whole course nursing intervention is helpful to promote the cooperation of the patients, raise the successful rate of TBNA, reduce the operation risk of patients, reduce the postoperative complications.