Abstract: Objective:To explore the diagnosis and treatment of nodular goiter.Methods:Seventy-three patients with nodular goiter were received B ultrasonic examination,pathological test and surgical treatment.Results:Eleven patients recurred,7 received the second operation,4 presented dysphagia and 5 developed hypoparathyroidism which was restored to normal by conservative therapy.Conclusions:Ultrasonograph should be routinely performed before operation,and CT is required for patients with large tumors,dysphagia or dyspnea.Subtotal thyroidectomy is suggested;the normal thyroid tissue should be reserved as much as possible,and the recurrent laryngeal nerve and parathyroid should be prevented from injury.