AECOPD病人CO<sub>2</sub>潴留与凝血指标变化的相关性分析

AECOPD病人CO₂潴留与凝血指标变化的相关性分析

摘要:
目的研究慢性阻塞性肺疾病急性加重期病人（AECOPD）血气分析二氧化碳分压（PCO₂）和凝血指标纤维蛋白原（FIB）、D-二聚体的相关性。
方法AECOPD病人排除可能并存对凝血指标有影响的疾病及相关因素者共计92例，分析PCO₂与FIB、D-二聚体的相关性。
结果AECOPD病人PCO₂增高组FIB、D-二聚体明显高于PCO₂正常组（P < 0.01）。PCO₂与FIB呈正相关关系（r=0.686，P < 0.05），PCO₂与D二聚体呈正相关关系（r=0.741，P < 0.05）。
结论AECOPD病人二氧化碳潴留越严重，凝血功能障碍的发生率越高。

Abstract:
ObjectiveTo study the correlations between the partial pressure of carbon dioxide (PCO₂) and levels of fibrinogen (FIB), D-dimmer in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
MethodsExcluding the possible coexisting disease and related factors affecting the coagulation indexes, the correlations between PCO₂ and levels of FIB, D-dimmer in 92 patients with AECOPD were analyzed.
ResultsThe levels of FIB and D-dimmer of AECOPD patients in PCO₂ increasing group were significantly higher than those in normal PCO₂ group (P < 0.01).The levels of FIB and D-dimmer were positively correlated with the PCO₂ (r=0.686, 0.741, P < 0.05).
ConclusionsThe more serious the carbon dioxide retention is, the higher the incidence of coagulation dysfunction is in AECOPD patients.