Abstract: Objective: To investigate the effect of flupenthixol combined with domperidone and hydrotalcit on chronic superficial gastritis.Methods: Eighty-three patients with chronic superficial gastritis were randomized into two groups.The control group(41 cases) were given domperidone 10 mg and hydrotalcite 1.0 g 3 time per day for 2 weeks.The treatment group(42 cases) were given one pill of flupenthixol in the morning and/or at noon for two weeks.The total response rate and the effect on each symptom between the two groups were analyzed statistically.Results: The total response rate in the treatment group(92.9%) was higher than that in the control group(73.2%) (P<0.05).The remission rates of epigastric distention,early satiety and belching were higher in the treatment group than that in the control group(P<0.05).The remission rates of the upper abdominal pain or epigastric discomfort were not significantly different between the two groups(P>0.05).Conclusions: Flupenthixol combined with domperidone and hydrotalcite can improve the therapeutic effect on chronic superficial gastritis.