Abstract: Objective: To study the function of coagulation,anti-coagulation and fibrinolysis in later-pregnant women,and to study the clinical value of prothrombin time(PT),activated partial thrombopastin time(APTT),fibrinogen(Fib) and D-dimer in later-pregnant women.Methods: Routine coagulation tests PT,APTT,Fib,D-dimer were determined in plasma of 35 later-pregnant women and 40 normal controls.Results: No significant difference were found in the amounts of PT in two groups(P>0.05),the amounts of APTT in later-pregnant women were lower than that in normal controls(P<0.05).The amounts of Fib and D-dimer in later-pregnant women were significantly higher than that in normal controls(P<0.001).Conclusions: The PT during pregnancy is not significant changed,PT can't indicate the activates coagulation state,however,all APTT,Fib and D-dimer can.D-dimer's increase in pregnant women also indicates the occurrence of secondary fibrinolysis.