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    董雪成, 李庆文. X连锁凋亡抑制蛋白在膀胱癌的表达及其意义[J]. 蚌埠医科大学学报, 2009, 34(3): 229-231.
    引用本文: 董雪成, 李庆文. X连锁凋亡抑制蛋白在膀胱癌的表达及其意义[J]. 蚌埠医科大学学报, 2009, 34(3): 229-231.
    shu
    DONG Xue-cheng, LI Qing-wen. Expression and significance of X-linked inhibitor of apoptosis protein in bladder cancer[J]. Journal of Bengbu Medical University, 2009, 34(3): 229-231.
    Citation: DONG Xue-cheng, LI Qing-wen. Expression and significance of X-linked inhibitor of apoptosis protein in bladder cancer[J]. Journal of Bengbu Medical University, 2009, 34(3): 229-231.
    shu

    X连锁凋亡抑制蛋白在膀胱癌的表达及其意义

    Expression and significance of X-linked inhibitor of apoptosis protein in bladder cancer

      摘要
    • 摘要: 目的:探讨X连锁的凋亡抑制蛋白(XIAP)在膀胱移行细胞癌(BTCC)的表达情况,以及XIAP与BTCC病理分级、临床分期的关系。方法:收集临床上经病理确诊的BTCC手术标本62例,应用免疫组织化学测定肿瘤组织中XIAP的表达情况,将结果进行相关分析。结果:XIAP在膀胱肿瘤中的阳性表达率为67.7%,在正常膀胱移行上皮阳性表达率为23.1%,两者差异有统计学意义(P<0.005);在Ⅰ、Ⅱ、Ⅲ级BTCC的阳性表达率分别是75.0%、57.9%和66.7%,在浅表性和浸润性BTCC的阳性表达率分别为63.9%和73.1%,阳性表达率各组之间无统计学意义(P>0.05)。结论:XIAP可能在BTCC的发生、发展中发挥重要作用。

       

      Abstract: Objective: To study the expression of X-linked inhibitor of apoptosis protein(XIAP) in bladder transitional cell carcinoma(BTCC) and to clarify the relationship between the pathological grades and clinical stages of BTCC.Methods: The epithelium speciment of 62 cases of BTCC confirmed by pathological method were collected and the expression of XIAP was detected by using immunohistochemical assay(SP methods).Results: The positive expression rate of XIAP in BTCC was 67.7%,which was significantly higher than that of normal bladder tissues(23.1%)(P<0.005).The positive expression rates in grade Ⅰ,Ⅱ and Ⅲ were 75.0%,57.9% and 66.7%,respectively;The positive expression rates in stage Ta-T1 and T2-T4 were 63.9% and 73.1%,respectively.Conclusions: It is suggested that high expression of XIAP may play an important role in the mechanisms of tumorignesis and development of BTCC.

       

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