重度子痫前期患者血清可溶性血管内皮生长因子受体1及胎盘组织中胎盘生长因子的表达及意义

张燕; 申庆文

重度子痫前期患者血清可溶性血管内皮生长因子受体1及胎盘组织中胎盘生长因子的表达及意义

张燕,
申庆文

Changes of the expression of placental growth factor in placenta and soluble fms-like tyrosine kinase-1 in serum of patients with severe pre-eclampsia and its clinical significance

摘要

摘要: 目的:探讨重度子痫前期患者血清中可溶性血管内皮生长因子受体1(soluble fms-like tyrosine kinase-1,sFlt-1)及胎盘组织中胎盘生长因子(placental growth factor,PLGF)表达的变化及其意义。方法:采用免疫组织化学S-P法对20例正常孕妇(对照组)和32例重度子痫前期患者胎盘组织中PLGF表达水平进行检测;并采用Imagepro Plus图像分析软件对结果进行定量分析。采用ELISA对2组血清中sFlt-1进行定量检测,并分析二者的相关性。结果:与对照组比较,重度子痫前期患者胎盘组织中PLGF的表达强度降低(P<0.05),血清中sFlt-1显著升高(P<0.01)。结论:血清sFlt-1和PLGF可能与重度子痫前期的病理学基础有关,对血清sFlt-1的监测有望作为早期预测子痫前期的方式。

Abstract: Objective: To study the changes of the expression of placental growth factor (PLGF) in placenta and soluble fms-like tyrosine kinase-1 (sFlt-1) in serum of patients with severe pre-eclampsia.Methods: Twenty normal pregnant women (control group) and 32 women with severe pre-eclampsia were selected.The expression level of PLGF in placenta among the two groups was determined by immunohistochemistry S-P mothod,and the results were analyzed with imagepro plus analysis software.The serum sFlt-1 level of the two groups was measured by ELISA.Results: The expression of PLGF in the trophoblast of patients with severe pre-eclampsia was lower than that in the control group (P<0.05),while the serum sFlt-1 level was significantly higher than that of the control group (P<0.01).Conclusions: The PLGF in placenta and sFlt-1 in serum may be related to the etiology of pre-eclampsia.The level of sFlt-1 in maternal serum may serve as a diagnostic marker of pre-eclampsia.

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