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    丁伯应, 杨小龙, 卢林明. 转录调节因子Ets-1在食管鳞癌的表达及其意义[J]. 蚌埠医科大学学报, 2008, 33(1): 48-50.
    引用本文: 丁伯应, 杨小龙, 卢林明. 转录调节因子Ets-1在食管鳞癌的表达及其意义[J]. 蚌埠医科大学学报, 2008, 33(1): 48-50.
    shu
    DING Bo-ying, YANG Xiao-long, LU Lin-ming. Expression and its significance of transcription factor Ets-1 in esophageal squamous cell carcinomas[J]. Journal of Bengbu Medical University, 2008, 33(1): 48-50.
    Citation: DING Bo-ying, YANG Xiao-long, LU Lin-ming. Expression and its significance of transcription factor Ets-1 in esophageal squamous cell carcinomas[J]. Journal of Bengbu Medical University, 2008, 33(1): 48-50.
    shu

    转录调节因子Ets-1在食管鳞癌的表达及其意义

    Expression and its significance of transcription factor Ets-1 in esophageal squamous cell carcinomas

      摘要
    • 摘要: 目的:探讨转录调节因子Ets-1在食管鳞癌组织的表达及其意义。方法:采用免疫组化技术(SP法)检测Ets-1在68例食管鳞癌组织及癌旁组织中的表达。结果:Ets-1在食管癌肿瘤组织高表达,远高于癌旁组织(P<0.005);Ets-1在肿瘤组织阳性表达率在不同病理分级、TNM分期各组中,差异均有统计学意义(P<0.05~P<0.01),而且Ets-1阳性表达率与病理分级、淋巴结转移和TNM分期均呈正相关关系(P<0.05~P<0.01)。未发现Ets-1在食管癌肿瘤组织的阳性表达率与病理类型有关(P>0.05)。结论:Ets-1在食管癌组织高表达,并与病理学分级、淋巴结转移及TNM分期有关。

       

      Abstract: Objective: To analyze the expression and its significance of Ets-1(E26 transformation-specific) in esophageal squamous cell carcinomas(ESCC).Methods: Tissue samples were collected from 68 patients who underwent surgery in our hospital from 1999 to 2005.The expression of Ets-1 in these samples by immunohistochemistry was detected.Results: Ets-1 protein expressed in esophageal carcinoma tissues is significantly higher than in pericancerous tissues(P<0.005).The expression of Ets-1 is positively correlated with the pathology grading,lymph node metastasis,and TNM stage of ESCC(P<0.05).The pathological type were no association with the Ets-1 protein expression positive rates in ESCC.Conclusions: The results indicated that Ets-1 was over expressed in ESCC tissues and correlated with its pathology grading,lymph node metastasis and TNM stage.

       

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