Abstract: Objective: To investigate the serum levels of high sensitivity C reactive protein (h-CRP), total bilirubin (TBil) and direct bilirubin (DBil) in patients with coronary arteriosclerosis and the correlation between their levels and arteriosclerosis. Methods: The levels of h-CRP was determined by latex-enhanced immunoturbidimetric, DBil and TBil were determined by continuous monitoring assay in 48 patients with coronary arteriosclerosis and 50 controls. Results: Compared with the control, the levels of h-CRP, DBil and TBil in these patients had statistically significant differences. The levels of h-CRP of these patients were higher than those of the control (P<0.001) while the levels of DBil and TBil were lower (P<0.001). Conclusions: The determination of the levels of hs-CRP, DBil and TBil in serum can help in evaluating the severity and the risk of coronary arteriosclerosis, which will prevent coronary artery disease.