Abstract: Objective: To evaluate the efficacy of oxcarbazepine in treatment of migraine. Methods: A randomized,double-blind and placebo-controlled trial was done in 120 cases of patients with migraine,including 54 patients accepted placebos as control group and 66 patients accepted oxcarbazepines as treatment group. Placepos and oxcarbazepines were used in the two groups for 8 weeks. The daily dose for the patients is 900 mg. The intensity of headache during the treatment was recorded by mothed of numeric rating scale(NRS:0-10 scale). The duration of each migraine attack(hours) and migrainer frequency(time/month) were recorded in 8 weeks. Results: All patients were observed for 8 consecutive weeks. The headache intensity, the duration of each migraine attack and frequency of headache in the treatment group were significantly decreased compared with that in the control group (P < 0.01). Conclusions: Oxcarbazepine is effective for prevening and treating of migraine.