Abstract: Objective:To investigate the effect of low-dose of erythromycin on feeding intolerance in premature infants. Methods:Seventy-four premature infants with feeding intolerance were randomly divided into treatment group (36 cases) and control group (38 cases). The control group received routine therapy, while the treatment group were administered intravenous injection of erythromycin 5 mg·kg^-1·d^-1 once a day for 5-7 days in addition to the routine therapy. Results:The therapeutic effect of treatment group was superior to the control group in the extinction time of vomiting, stomach retention and abdominal distension as well as the time of nutrition getting full into the gastrointestinal tract and achieving birth weight(P<0.05). Diarrhea occurred in 2 cases in the treatment group and 1 case in the control group. There wasn't statistical significance(P>0.05). Conclusions:The erythromycin in lowdose can improve the feeding into intolerance of premature children. It is worthly of application.