Abstract: Objective: To sum up the experience in treating femoral shaft fracture with interlocking intramedullary nail.Methods: Sixty-two cases of femoral shaft fractures were treated with close reduction or limited open reduction,reamed marrow cavity and static fixation and target devices were used to lock the fracture.Results: All the cases were followed up for 6 to 8 months.All the fractures were healed.The effect was excellent in 39 cases,good in 17 cases and poor in 4 cases according to the criteria of Ma Yuanzhang.Conclusions: Interlocking intramedullary nail is the choice of treatment for femoral shaft fracture.It has the advantages of firm fixation,good healing,good articular function,few complications and manipulation easy.It is worth popularizing.