非小细胞肺癌微血管密度的研究

Study on microvessel density in non-small cell lung cancer

摘要: 目的: 探讨非小细胞肺癌组织中微血管密度(microvessel density,MVD)与肺癌临床病理特征的关系。方法: 采用S-P免疫组化法,检测57例肺癌组织MVD,研究微血管表达与非小细胞肺癌病理分型、临床分期及淋巴结转移的关系。结果: MVD与肺癌淋巴结转移状态、分期、细胞分化程度等均有密切关系(P<0.01),而与肺癌患者性别、组织学类型、原发肿瘤大小等均无明显关系(P>0.05)。结论: MVD在肺癌的发生、发展、转移中起重要作用,可以作为评价非小细胞肺癌预后指标之一。

Abstract: Objective: To study the relationship between microvessel density(MVD) of non-small cell lung cancer(NSCLC) tissues and the clinicopathological characteristics.Methods: The MVD was detected in 57 NSCLC tissues by immunohistochemical staining(S-P method) and the relationship of MVD to the clinical staging,pathologic typing and lymph node metastasis was studied.Results: MVD was closely related to the lymph node status,clinical staging and grade of cell differentiation of NSCLC(P<0.01),but not to the size of primary cancer,the histological classification and sex(P>0.05).Conclusions: MVD may play an important role in the oncogenesis,development and metastasis of NSCLC and is one of the reliable prognostic indicator of survials of NSCLC.