Abstract: Objective:To investigate the therapeutic efficiency of open reduction internal fixation with locking compression plate on comminuted distal radial fractures.Methods:Twenty-one cases of comminuted distal radial fractures that failed with closed reduction were treated with open reduction.internal fixation with locking compression plate.The healing of bone and long-term functional result were followed up.Results:All cases were followed up between 6-13 months.All the fractures were united and the the healing time was between 49-56 days.There were no complications such as infection,nonunion,breakage of the implants,or restriction of finger extension.According to the modified Green and O'Brien criteria of fracture,14 cases were excellent and 7 cases were good.Conclusions:To treat the comminuted distal radial fractures that failed with closed reduction,open reduction and internal fixation with locking compression plate can achieve satisfied results.