胃癌组织中D2-40标记的微淋巴管密度与幽门螺杆菌L型感染的关系研究

田甜; 于东红

胃癌组织中D2-40标记的微淋巴管密度与幽门螺杆菌L型感染的关系研究

田甜,
于东红

Correlation between lymphatic microvessel densities marked by monoclonal antibody D2-40 and helicobacter pylori L-form infection in gastric carcinoma

摘要

摘要: 目的:探讨人胃癌组织中D2-40标记的微淋巴管密度(lymphatic microvessel density,LMVD)与幽门螺杆菌L型(Helicobacter pylori L-form,Hp-L型)感染的关系。方法:采用免疫组织化学S-P法检测100例胃癌、50例对应癌旁及30例切缘正常对照组织D2-40和Hp-L型抗原的表达;采用革兰染色法检测上述组织的Hp-L型的感染情况。结果:胃癌癌中心区LMVD为每100倍视野12.61±4.20个,切缘正常对照组LMVD为每100倍视野9.23±5.62个,癌旁组织LMVD为每100倍视野31.20±3.73个,癌旁组的LMVD均显著高于胃癌癌中心区和切缘正常对照组(P<0.01),且与胃癌淋巴结转移数目及Hp-L型的检出率有一定的关系(P<0.01)。结论:胃癌组织中D2-40单抗标记的LMVD与Hp-L感染有密切关系。

Abstract: Objective: To investigate the relationship between lymphatic microvessel density marked by monoclonal antibody D2-40 and Helicobacter pylori L-form (Hp-L) infection in gastric cancer.Methods: The expression of D2-40 and Hp-L in the tissue samples of 100 cases of gastric cancer,50 cases of peritumoral tissues and 30 normal gastric tissues were detect by S-P immunohistochemistry;and Hp-L infection of the above tissues was calculated by Gram stain.Results: The LMVD was 12.61±4.20 per 100 visual field in the central area of the tumor;and the LMVD was 31.20±3.73 per 100 visual field in the peritumoral tissues,which was significantly higher than that in the central area of the tumor and the normal gastric tissues 9.23±5.62 per 100 visual field (P<0.01);the number of LMVD was significantly correlated with that of metastatic lymph nodes and Hp-L infection (P<0.01).Conclusions: The lymphatic microvessel density marked by monoclonal antibody D2-40 is correlated with Hp-L infection.

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