<sup>131</sup>I治疗分化型甲状腺癌转移灶疗效观察

¹³¹I治疗分化型甲状腺癌转移灶疗效观察

摘要: 目的:观察分化型甲状腺癌并远处转移患者接受多次大剂量¹³¹I治疗的临床效果。方法:45例分化型甲状腺癌并远处转移患者,根据甲状腺癌转移部位给予患者每次口服¹³¹I(370~740)×10⁷Bq,分2~8次用药,每2次间隔4~12个月;治疗后4~6个月,采用¹³¹I全身显像和血清甲状腺球蛋白评价治疗效果。结果:45例中临床治愈15例,有效26例,无效4例。结论:多次¹³¹I治疗分化型甲状腺癌转移灶疗效佳,副作用小。

Abstract: Objective: To assess the effect of iodine-131(¹³¹I) therapy on patients with differentiated thyroid carcinoma metastases.Methods: Forty-five patients with differentiated thyroid carcinoma metastases were treated with ¹³¹I,and the dose of ¹³¹I varied according to the site of metastasis(370×10⁷ to 740×10⁷) Bq.The therapy was repeated 2 to 8 times at an interval of 4 to 12 months.The efficacy was assessed 4-6 months later with ¹³¹I whole body scanning and serum level of thyroglobulin.Results: Of the 45 cases,15 were cured,26 improved and 4 had no response.Conclusions: The therapy of high doses of ¹³¹I is safe and effective for treatment of differentiated thyroid carcinoma metastases with little adverse side-effect.