Abstract: Objective:To reconstruct and visualize the three-dimensional model of the precentral sulcus and its adjacent domains for stereotactic anatomy,interventional radiology and minimal invasive surgery.Methods:The precentral sulcus,longitudinal fissure,the lateral ventricle,the cerebrum surface profile of the head were identified and segmented on MRI transverse of six healthy volunteer's heads,and their three-dimensional models were reconstructed in 3D-Doctor software package with the method of surface rendering.Results:The first successful three-dimensional model of the precentral sulcus was reconstructed.The precentral sulcus,other interesting structures and their spatial relations were observed in three-dimensional virtual space in random angles.Conclusions:It is hoped that the three-dimensional reconstruction and visualization of the precentral sulcus based on the MRI would benefit for the study of neuroanatomy,stereotactic neurosurgery,remote imaging diagnosis and multimedia teaching.