血清内脂素与急性冠状动脉综合征的相关性

Study on the relationship between serum visfatin levels and acute coronary syndrome

摘要: 目的:探讨血清内脂素与急性冠状动脉综合征(ACS)的关系及其在斑块失稳定性中的作用。方法:采用ELISA方法分别检测40例ACS(ACS组)、22例稳定型心绞痛(SAP组)和26例非冠心病患者(对照组)的血清内脂素及基质金属蛋白酶-9(MMP-9)水平,并比较两者相关性。结果:ACS组血清内脂素和MMP-9水平均显著高于SAP组和对照组(P<0.01)。ACS患者中血清内脂素与MMP-9呈显著正相关关系(P<0.01)。结论:血清内脂素与ACS具有相关性,可作为预测斑块稳定性的标志物,对其测定有助于ACS的早期防治。

Abstract: Objective:To study the relationship of serum visfatin levels and acute coronary syndrome(ACS) and the role of serum visfatin in vulnerable plaques. Methods:The serum levels of visfatin and matrix metalloproteinase-9(MMP-9) in 40 cases with ACS,22 cases with stable angina pectoris(SAP) and 26 control cases were measured by ELISA,and the correlation between visfatin and MMP-9 was evaluated. Results:The levels of visfatin and MMP-9 in cases with ACS were significantly higher than those in SAP and control groups(P<0.01). Significant positive correlation of visfatin and MMP-9 in patients with ACS were found(P<0.01). Conclusions:The serum levels of visfatin and ACS exist correlation. Visfatin may act as the biomarkers of vulnerable plaques and be applied in the early prevention and management of ACS.