Abstract: Objective: To study the curative effects of upper respiratory stenosis surgery in combination with continuous positive airway pressure(CPAP) in treatment of obstructive sleep apnea syndrome(OSAS). Methods: Eighty OSAS patients were romdomly divided into two groups:combined modality therapy group and control group. The control group received the surgery on the upper respiratory stenosis of nasal and pharynx cavity; the combined modality therapy group received surgery on the stenosis of nasal and pharynx cavity on the basis of accurate judgment of the upper respiratory obstructive flat with the assistance of CPAP therapy. Results: All the cases were followed up fro 6-12 months. The outcomes were assessed by polysomnogruphy. In the combination therapy group,the effects were excellent in 19 cases,fair in 16 cases and invalid in 5 cases. The total response rate was 87.5%. In the control group,the effect was excellent in 7 cases,fair in 18 cases and invalid in 15 cases. The total response rate was 62.5%. The difference was significant(P < 0.05). Conclusions: The combination therapy of upper respiratory stenosis surgery and CPAP has significant advantages in treatment of OSAS and is worth popularizing.