Abstract: Objective: To analyze the clinic features of viral encephalitis caused by hand-foot-mouth disease (HFMD),and to explore its diagnosis,treatment and prognosis.Methods: Sixty-five cases of HFMD were diagnosed and methyllprednisolone,gamma globulin assaulting,dewatering and resisting virus therapies were applied.Results: The major clinical manifestations of the 65 cases were skin rash,fever,drowsiness,limbs shaking and emesia.The symptoms of viral encephalitis appeared on the second to the fourth day following the onset of the disease.Sixty-three cases were cured and 2 cases had nervous system residual when discharged.Conclusions: The viral encephalitis caused by HFMD is most frequently observed in children below the age of three.The symptoms of nerve system are not typital.Early diagnosis and treatment are essential to successful remedy.Delayed treatment may lead to never system residual and death.