Abstract: Objective: To investigate the efficacy and complication of high dose of corticosteroid in treatment of proliferative hemangiomas of infants. Methods: The proliferative hemangioma infants were administered prednisone in the first 8 weeks according to their wight (4 mg/kg) and the dosage was decreased to 2 tablets in the 9th week and 1 tablet in the 10th week;the medicine was taken orally once every two days at 8-9 am for 10 weeks. The outcome of treatment, courses of therapy, and short and long term of side effects were analyzed. Results: The overall response rate was 90% in proliferative hemangiomas infants treated with Corticosteroid;92% of the infants entered into stable involuting stage with no serious short or long term complications after 1-2 courses. Conclusions: 1-2 courses of high dose of corticosteroids provide a safe and effective modality for treatment of proliferative hemangiomas in infants. It is worth popularizing.