双侧附睾原发性恶性淋巴瘤(附1例报道及文献复习)

Primary malignant lymphoma of the bilateral epididymus: Case report and review of the literature

摘要: 目的: 探讨双侧附睾原发性恶性淋巴瘤的临床病理特征。方法: 报道1例42岁双侧附睾原发性恶性淋巴瘤,手术标本经光镜及免疫组化检查,并进行文献复习。结果: 表现为无痛性双侧附睾肿大,病理诊断为黏膜相关淋巴组织结外边缘区B细胞恶性淋巴瘤。免疫表型CD45、CD20、CD79α阳性,CD45RO、CD3、细胞角蛋白(CK)、胎盘碱性磷酸酶(PLAP)阴性。结论: 双侧附睾原发性恶性淋巴瘤极为罕见,根据组织学特点,结合免疫组化染色,可以明确诊断。

Abstract: Objective: To study the clinical and pathological features of primary malignant lymphoma of the bilateral epididymus.Methods: The surgical specimens of a 42-year-old man with primary malignant lymphoma of the bilateral epidiymus were observed by light microscopy and immunohistochemistry,and the literature was reviewed.Results: The patient presented with painless bilateral epididymal enlargement and the extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue(MALT) was diagnosed by histopathology.The expression of CD45,CD20 and CD79α in the tumor cells was positive,while the expression of CD45RO,CD3,cytokeration(CK) and placental alkaline phosphatase(PLAP) was negative.Conclusions: Primary malignant lymphoma arising in the epididymis is a rare entity.The diagnosis mainly relies on histopathological and immunohistochemical findings.