Abstract: To study the expression and significance of sup ressorand nevustieeuee_ Methods:Tmmunohistnchemical S methyl was usedof cytokine in detectsignaling 3(SOCS3)in cutaneous melanomathe proteinmetalloproteinases(MMP 2). linical and pathologic featuresand MMP3 of 90caeee with melanoma and 43 caeee with nevusan硬of all patients. Results:The positive expression of SOCS3 in melanomaof nevus tissues(40% and 60.5% respectively p0. OS),and. The low expression of SOCS3 was expression of SOCS3,matrix analysed the relation with thewas significantly lower than thatcorrelated to the diameters andinvasive depth of tumors and metastasis of lymph node(p0. OS to p0. O1)Compared with the cases with negative expression ofSOCS3,the cases with melanoma with positive SOCS3 expression had significantly longer relapseree survival and overall survival(p0.01). SOCS3 expression was inversely correlated with the expression of MMP 2 and MMP(p0. OS and p0. O1). Conclusions:The expression of SOCS3 was closely related to the tumor growth invasion and metastasis SOCS3 may play an important role on theinvasive growth of human cutaneous melanoma