eIF4E和CyclinD1在子宫内膜增生症和子宫内膜样腺癌中的表达及其意义

孙乐水; 葛霞

eIF4E和CyclinD1在子宫内膜增生症和子宫内膜样腺癌中的表达及其意义

孙乐水,
葛霞

Expression and significance of eIF4E and CyclinD1 in endometrial hyperplasia and endometrial carcinoma

SUN Le-shui,
GE Xia

摘要

摘要: 目的:探讨eIF4E、CyclinD1在子宫内膜增生症和子宫内膜样腺癌中的表达及其临床意义。方法:应用免疫组织化学Eli-Vision法检测80例子宫内膜增生症和65例子宫内膜样腺癌中eIF4E、CyclinD1的表达情况,并选取15例正常增生期子宫内膜作对照,结合患者的临床病理参数进行分析。结果:eIF4E在正常增生期子宫内膜组织、单纯性增生子宫内膜组织、复杂性增生子宫内膜组织、不典型增生子宫内膜组织和子宫内膜样腺癌组织中阳性表达率分别为53.33%、72.50%、80.00%、84.00%和90.77%,eIF4E蛋白阳性表达仅子宫内膜样腺癌与正常增生期子宫内膜差异有统计学意义(P0.01);CyclinD1阳性表达率分别为6.67%、52.50%、73.33%、80.00%和81.54%,表达率呈上升趋势,CyclinD1仅子宫内膜样腺癌、不典型增生、复杂性增生与正常增生期子宫内膜差异均有统计学意义(P0.01)。子宫内膜样腺癌中eIF4E、CyclinD1阳性表达与临床-病理分期、组织学分级和有无淋巴结转移间差异均无统计学意义(P0.05)。在子宫内膜样腺癌中,eIF4E、CyclinD1表达呈正相关关系(P0.01)。结论:eIF4E、CyclinD1在子宫内膜样腺癌中均高表达,两者的异常表达共同作用促进子宫内膜样腺癌的发展,两者有协同作用。

Abstract: Objective:To study the expression and clinical significance of eIF4E and CyclinD1 in endometrial hyperplasia and endometrial carcinoma.Methods:The expressions of eIF4E and CyclinD1 in 40 cases of simple hyperplasia,40 cases of complex hyperplasia(25 cases of atypical hyperplasia),65 cases of endometrial carcinoma and 15 cases of normal proliferative endometrium were detected by means of immunohistochemical EliVision,the related pathological parameters were analyzed.Results:The positive expression of eIF4E in normal proliferative endometrium,simple endometrial hyperplasia,complex endometrial hyperplasia,atypical hyperplasia and endometriod adenocarcinoma was 53.33%,72.50%,80.00%,84.00% and 90.77%,respectively;while the positive expression of CyclinD1 was 6.67%,52.50%,70.33%,80.00% and 81.54%,respectively.The expression of eIF4E was only significantly different between the endometrial carcinoma and the normal proliferative endometrium(P0.01);the expression of CyclinD1 in endometriod adenocarcinoma,atypical hyperplasia and complex endometrial hyperplasia was significantly different from that in normal proliferative endometrium.The positive expression of eIF4E and CyclinD1 in endometriod adenocarcinoma was not obviously related to the TNM stage,pathological grade or lymph node metastasis(P0.05).Statistical analysis showed that there was a positive correlation between eIF4E and CyclinD1 expression in endometriod adenocarcinoma(P0.05).Conclusions:EIF4E and CyclinD1 are both over-expressed in endometrial carcinoma,and the synergy of them may contribute to the development of endometrial carcinoma.

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