Abstract: Objective:To evaluate the diagnostic value of endoscopic ultrasonography(EUS) in eminence lesion of the stomach.Methods:EUS and mini-probe sonography were performed in 186 patients with eminence lesion of the stomach which had been detected by the gastroscopy.Excepting for 45 cases of protuberance from outside organs,5 cases of sub-mucous hemartoma and 7 cases of varicosity,all the cases were confirmed by surgical operation or biopsy.The pathological and diagnostic results by the two methods were compared.Results:One hundred and four cases had sub-mucous tumors,most of which were gastric stromal tumors,and 82 nontumorous lesions,most of which were protuberance from outside organs.The diagnose accordance rate was 93.0% by EUS and 74.2% by endoscopy.The difference was significant(P0.01).Conclusions:EUS can display the layers of the digestive tract wall and the lesions outside the wall,which is of great help for the diagnosis and differential diagnosis of eminence lesion of the stomach.