淮北地区肠杆菌科细菌对21种抗生素的耐药性分析

张琪; 程训民; 朱素珍; 李敏

淮北地区肠杆菌科细菌对21种抗生素的耐药性分析

Analysis on enterobacter resistance to 21 antibiotics in Huaibei area

摘要

摘要: 目的: 了解21种抗生素对淮北地区肠杆菌科细菌的体外抗菌活性,指导临床有效合理用药。方法: 收集淮北地区分离的326株肠杆菌科细菌,采用Micro Scan WalkAway-40、Vitek-32全自动微生物分析仪和K-B法进行菌种鉴定和耐药性分析,按照1999年NCCLS的标准进行结果判断。结果: 在检测的326株肠杆菌科细菌中,分离出大肠埃希菌216株,肺炎克雷伯菌37株,鼻硬结克雷伯菌18株,聚团多源菌19株,产气肠杆菌18株,阴沟肠杆菌18株。大肠埃希菌、肺炎克雷伯菌等对亚安培南的耐药率最低,分别为1.4%和2.8%。其次为哌拉西林/他唑巴坦和头孢哌酮/舒巴坦,另外庆大霉素和阿米卡星耐药率也较低。结论: 所测试的21种抗生素中亚安培南是治疗的首选药物,临床治疗时应根据具体菌种及实验室药敏结果合理选择抗生素。

Abstract: Objective: To analyze and compare the anti-bacterial effects of 21 antibiotics on the nitrobacteria isolated from 3 hospitals in Huaibei area in order to direct proper use of drugs in clinics.Methods: A total of 326 nitrobacteria were tested by Micro Scan WalkAWay-40,Vitek-32 and Kirby-Beuer for drug sensitivity.The susceptibility test was conducted according to NCCLS formulated in 1999.Results: Among 326 strains of enterobacteriaceae were isolated Escherichia coli(216),Klebsiella pneumoniae(37),Klebsiella rhinoschleromatis(18),Enterobacter agglomerans(19),Enterobacter aerogenes(18) and Enterobacter cloacae(18).Escherichia coli and Klebsiella pneumoniae resistance to imipenem were the lowest(1.4% and 2.8%),and then were cefoperazon/sulbactam,piperacillin/tazobactam,gentamicin,amikacin.Conclusions: Of the 21 antibiotics tested,Imipenem is the most sensitive one.Clinical treatment should be performed according to the results of the susceptibility test.

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