Abstract: Objective: To investigate the effects of perioperative psychological support therapy on cognitive function of elderly patient with femoral neck fracture.Methods: Thirty-four cases with femoral neck fracture treated with internal fixation under general anesthesia were randomly divided into perioperative psychological support therapy group(PPST group) and control group(17 cases each group).The blood pressure(BP),heart rate(HR),pulse oxygen saturation and electrocardiography of two groups were observed during the operation.The mean artery pressure(MAP) and HR of two groups were recorded during extubation and at 5 minutes after extubation.mini-mental state examination(MMSE) scores of two groups were recorded before anesthesia and at 3,6,24 and 72 hours after operation,which was used to evaluate their cognitive function.Results: The levels of MAP and HR of two groups during extubation and at 5 minutes after extubation were higher than those after operation(P 0.01),but the increasing degree of control group was significantly higher than that in PPST group(P 0.01).Compared with preanesthesia,MMSE scores decreased significantly at 3 hours after operation in PPST group(P 0.01) and the control group decreased significantly at 3,6 and 24 hours after operation(P 0.01),the differeces of MMSE scores in two groups were not statistical significance at 72 hours after operation(P 0.05).MMSE scores of control group were lower than that in PPST group at 3,6 and 24 hours after operation(P 0.05 to P 0.01).Conclusions: Perioperative psychological support therapy can significantly reduce the incidence of postoperative cognitive dysfunction of elderly patient with femoral neck fracture and improve the relative stability of patients' circulation before and after the extubation,which keep patient stable during perioperative period.