Abstract: Objective: To investigate the clinic characteristics,diagnosis and treatment of tuberculosis in patients with systemic lupus erythematosus(SLE).Methods: The data of 39 SLE patients with tuberculosis were analyzed retrospectively including the clinic manifestations,imaging data,laboratory examination results,diagnosis and treatment conditions.Results: In 39 SLE patients with tuberculosis,pulmonary tuberculosis were happened in 18 cases,extrapulmonary tuberculosis in 19 cases,pulmonary tuberculosis complicated with extrapulmonary tuberculosis in 2 cases.Tuberculosis in SLE patients with complex and diverse clinical manifestations such as fever was occurred in 39 cases,lack of power in 37 patients,night sweats in 25 cases,cough in 20 cases.All patients were using anti-tuberculosis treatment after diagnosis,the treatment course was 9 months to 1.5 years.Three cases was dead,the remaining patients tended to cure by the standardized treatment of tuberculosis disease.Conclusions: Tuberculosis in patients with SLE has complex and varied clinic symptoms,it's different from simple tuberculosis and typical SLE.It is needed to notice if there was combined with other pathogens infection.Treatment needs to give consideration to the basic disease and tuberculosis.Early diagnosis and standardization of anti-tuberculosis are the important means which can improve the prognosis.