Abstract: Objective: To assess the value of fundus fluorescence angiogiaphy(FFA) in diagnostic of early diabetic retinopathy(DR) that had failed to be detected by ophthalenosope.Methods: One hundred and one patients(202 eyes) with non-insulin-dependent diabetes mellitus who had been proved to have no DR by ophthalenosope received FFA examination.Results: Forty-five patients(90 eyes) were found to have early DR by FFA.The lesions included capillaries lump,capillary non-perfusion,capillary fluorescence leakage,telangiectasis and macular edema.Conclusions: Fundus fluorecein angiography can detect diabetic retinopathy earlier than ophthalenosope.