Abstract: Objective:To investigate the correlation of preoperative serum squamous cell carcinoma antigen(SCCAg) with early-stage lymphatic metastasis of squamous cell cervical cancer.Methods:The clinically pathologic data of 391 cases with early-stage squamous cell cervical cancer undergoing radical hysterectomy were analyzed preoperatively.The serum levels of SCC-Ag preoperation were detected,and its correlation with the clinically pathologic data were statistically analyzed.Results:The levels of SCCAg preoperative and the FIGO staging,tumor size,depth of muscular infiltration,parametrial involvement and lymphatic metastasis had significantly association(P0.01),but the degree of differentiation and tumor vascular invasion was not statistically significant(P0.05).The lymph node metastasis and tumor diameter were the independent risk factors of affecting serum marker levels and lymphatic metastasis had more effects on the levels of SCC-Ag than tumor diameter.The better sensitivity(0.54) and specificity(0.83),highest Yonden index(0.37) and best predictive results could be achieved when the cut-off value was 2.5 ng/ml during the Ⅰb1 stage period.But forⅠb2 and Ⅱa stage,the cut-off value was 4.5 ng/ml.Conclusions:The serum levels of SCC-Ag preoperation have a certain value in evaluating the lymphatic metastasis.During Ⅰb1 and Ⅰb2 and Ⅱa.stage,the predictive results are the best when the cut-off values are 2.5 and 4.5 ng/ml respectively.