Abstract: Objective:To investigate the perioperative nursing experience of patients with coronary artery bypass grafting(CABG).Methods:Psychological nursing,monitoring blood glucose and blood pressure,improving heart and lung function,preventing angina pectoris,improving myocardial ischemia and protecting lower limb vein were carefully preparated before operation.Maintaining stability of circulatory,strengthening management of respiratory tract and respiratory support and keeping drainage duct open were carried out,meanwhile keeping adequate sedation,monitoring blood glucose,maintaining the balance of water,electrolyte and acid-base,guiding diet,nutrition and nursing limb were implemented after operation.Results:The complications included ventricular fibrillation in 1 case,supraventricular heartbeat over in 8 cases,premature ventricular contraction in 3 cases,intrathoracic hemorrhage in 5 cases,death in 8 cases,counterpulsation after application of intra aortic balloon in 1 case,incision infection in 4 cases and lower extremity deep vein thrombosis in 1 case.The average hospital stay was 28 days.Conclusions:Preoperative full preparation,postoperative monitoring all system,nursing of drainage tube and good health guidance can effectively help patients through the critical time of surgery.