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    石玉荣, 耿建, 甘怀勇, 章尧. 细胞色素P4501A1在子宫颈鳞状细胞癌组织中的表达及其临床意义[J]. 蚌埠医科大学学报, 2013, 37(8): 929-931.
    引用本文: 石玉荣, 耿建, 甘怀勇, 章尧. 细胞色素P4501A1在子宫颈鳞状细胞癌组织中的表达及其临床意义[J]. 蚌埠医科大学学报, 2013, 37(8): 929-931.
    shu
    SHI Yu-rong, GENG Jian, GAN Huai-yong, ZHANG Yao. The expression and clinical significance of cytochrome P4501A1 in squamous cell carcinoma[J]. Journal of Bengbu Medical University, 2013, 37(8): 929-931.
    Citation: SHI Yu-rong, GENG Jian, GAN Huai-yong, ZHANG Yao. The expression and clinical significance of cytochrome P4501A1 in squamous cell carcinoma[J]. Journal of Bengbu Medical University, 2013, 37(8): 929-931.
    shu

    细胞色素P4501A1在子宫颈鳞状细胞癌组织中的表达及其临床意义

    The expression and clinical significance of cytochrome P4501A1 in squamous cell carcinoma

      摘要
    • 摘要: 目的:探讨细胞色素P4501A1(cytochrome P4501A1,CYP1A1)在子宫颈鳞状细胞癌(SCC)中的表达及其临床意义。方法:采用免疫组织化学法检测18例正常子宫颈组织、33例子宫颈上皮内瘤变(CIN)组织和124例SCC组织中CYP1A1的表达。分析其表达与SCC的临床病理学参数及预后的关系。结果:CYP1A1在SCC组织中的阳性率(59. 7%)高于正常子宫颈组织(11. 1%)(P0. 05);在SCC病理分级细胞分化Ⅲ级中CYP1A1的阳性率(69. 8%)高于SCC细胞分化Ⅰ级者(34. 8%)(P0. 05)。在有淋巴结转移SCC组织中CYP1A1的阳性率(73. 6%)高于无淋巴结转移者(49. 3%)(P0. 01),CYP1A1表达在SCC的年龄、浸润程度、临床分期和肿瘤大小间差异均无统计学意义(0. 05)。结论:CYP1A1的高表达可能与SCC的发生、发展等生物学行为有关。

       

      Abstract: Objective: To investigate the expression and clinical significance of cytochrome P4501A1 ( CYP1A1) in squamous cell carcinoma( SCC) . Methods: The expressions of CYP1A1 in normal cervix tissue( 18 cases) ，cervical intraepithelial neoplasia( CIN)tissue( 33 cases) and SCC tissue ( 90 cases) were detected by immunohistochemicalstaining. The relationships between CYP1A1expression and clinicopathological features and prognosis of cervical cancer wereanalyzed. Results: The positive expression rate of CYP1A1 in SCC( 59. 7%) was higher than that in normal cervix(11. 1%) ( P ＜0. 05) . The positive expression rate of CYP1A1 in stage Ⅲ SCC( 69. 8%) was obviously higher than that in stageⅠ( 34. 8%) ( P ＜ 0. 05) . The positive expression rate of CYP1A1 in SCC with lymphnode metastases( 73. 6%) was higher than that in non-lymphnode metastases( 49. 3%) ( P ＜ 0. 05) . The expression differences of CYP1A1 in age，depth of invasion， stage and size of tumor had no statistic sigificance( P ＞ 0. 05) . Conclusions: The high expression of CYP1A1 may be associated with the occurence and development of cervical cancer.

       

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