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    郭晋, 伍德生, 吴晓飞. 依达拉奉对百草枯中毒肺损伤患者血清IL-6和TNF-的影响[J]. 蚌埠医科大学学报, 2013, 37(8): 939-940,943.
    引用本文: 郭晋, 伍德生, 吴晓飞. 依达拉奉对百草枯中毒肺损伤患者血清IL-6和TNF-的影响[J]. 蚌埠医科大学学报, 2013, 37(8): 939-940,943.
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    GUO Jin, WU De-sheng, WU Xiao-fei. The effect of edaravone on the levels of serum interleukin-6 and tumor necrosis factor- in lung injury patients induced by paraquat poisoning[J]. Journal of Bengbu Medical University, 2013, 37(8): 939-940,943.
    Citation: GUO Jin, WU De-sheng, WU Xiao-fei. The effect of edaravone on the levels of serum interleukin-6 and tumor necrosis factor- in lung injury patients induced by paraquat poisoning[J]. Journal of Bengbu Medical University, 2013, 37(8): 939-940,943.
    shu

    依达拉奉对百草枯中毒肺损伤患者血清IL-6和TNF-的影响

    The effect of edaravone on the levels of serum interleukin-6 and tumor necrosis factor- in lung injury patients induced by paraquat poisoning

      摘要
    • 摘要: 目的:探讨依达拉奉对百草枯中毒肺损伤患者血清白介素-6(IL-6)和肿瘤坏死因子-(TNF-)的影响。方法:40例百草枯中毒患者随机分为对照组(常规治疗)和治疗组(依达拉奉+常规治疗)。依达拉奉治疗剂量为30 mg,加入0. 9%氯化钠注射液250 ml静脉输注,每天2次,连用14 d。检测2组患者治疗前和治疗后血清IL-6和TNF-水平的变化。结果:治疗前对照组与治疗组患者血清IL-6和TNF-水平差异均无统计学意义(0. 05)。治疗后2组患者血清IL-6和TNF-水平均较治疗前明显降低(P0. 01),且治疗组血清IL-6和TNF-水平均较对照组显著下降(P0. 01)。结论:依达拉奉能有效降低百草枯中毒患者血清IL-6和TNF-水平,可减轻对肺的损伤。

       

      Abstract: Objective: To explore the effects of edaravone on the levels of serum interleukin-6 ( IL-6) and tumor necrosis factor-( TNF-) in lung injury patients induced by paraquat poisoning. Methods: Forty patients with paraquat poisoning were randomly divided into control group and treatment group. The control group were treated with routine therapy， the treatment group were treated with 30 mg of edaravone twice a day for 14 days combined with routine therapy. The levels of serum IL-6 and TNF- in two groups were measured before and after treatment. Results: The levels of serum IL-6 and TNF- in two groups before treatment were not statistical significance( P ＞ 0. 05) . The levels of serum IL-6 and TNF- in two groups after treatmentobviously decreased( P ＜ 0. 01) . Compared with control group， the decreasing IL-6 and TNF- levels in treatment group aftertreatment were obviously more ( P ＜ 0. 01 ) . Conclusions: Edaravone can effectively decrease the serum levels of IL-6 and TNF- and alleviate the lung injury in patients induced by paraquat poisoning.

       

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