Abstract: Objective: To explore the characteristics and related factors of coronary artery lesions in patients with premature coronary heart disease. Methods: One hundred and two patients diagnosed coronary heart disease by coronary angiography were divided into early onset group(43 cases,male ＜ 55 years old and female ＜ 65 years old) and late onset group(59 cases,male 55 years old and female 65 years old) . The characteristics and related factors of coronary artery lesions of two groups were analysed. Results: The proportion of single vascular lesions in patients with premature coronary heart disease were significantly higher than that of late onset coronary heart disease group(P ＜ 0. 01) . The smoking rate, family history of ischemic cardiovascular disease,body mass index,blood triglycerides, hemoglobin and blood fibrinogen levels of early onset group were obviously higher than that of late onset group(P ＜ 0. 05 to P ＜ 0. 01) . The uric acid levels of early onset group were lower than that of late onset group(P ＜ 0. 05) . Conclusions: The incidence of premature coronary artery disease is closely related to the family history of ischemic cardiovascular disease, fat,high blood triglycerides and the blood fibrinogen level. The proportion of single vascular lesions is more than that of late onset group. To prevent the coronary heart disease should actively control the related risk factors of cardiovascular disease as soon as possible.